Shortened therapy effective in babies with GBS infections
Study Rundown: GBS is the most common bacterial infection in infants, with no significant change in rates of late onset GBS infection (occurring at 7 to 90 days of age). Current guidelines published by the Committee on Infectious Diseases recommend prolonged IV antibiotic therapy (10 days) for uncomplicated GBS bacteremia. The purpose of this study was to compare rates of failure in subjects with late onset GBS who received prolonged (10 days) or shortened (≤8 days) antibiotic therapy. The primary outcome, recurrent GBS infection (defined as hospital revisit with a discharge diagnosis of GBS bacteremia, meningitis, or osteomyelitis within the first year of life) occurred at low rates in both the prolonged and shortened IV therapy groups, with no significant differences between the rates. Treatment failure (defined as recurrence of GBS disease 14 days from hospital discharge) similarly occurred at low rates in both groups, without significant differences between rates. The study was limited by reliance on medical coding, although validating testing was performed, and lack of data on possible use of outpatient antibiotics following admission. These data suggest that shortened IV therapy may be a reasonable alternative to prolonged IV therapy in GBS infection, preventing prolonged hospital stays and iatrogenic infections.